Synthesis of melatonin analogues derived from furo[2,3-b]- and [2,3-c]pyridines by use of a palladium-copper catalyst system | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1164334

Reference Type

Journal Article

Title

Synthesis of melatonin analogues derived from furo[2,3-b]- and [2,3-c]pyridines by use of a palladium-copper catalyst system

Author(s)

Van de Poel, H; Guillaumet, G; Viaud-Massuard, MC

Year

2002

Is Peer Reviewed?

Yes

Journal

Heterocycles
ISSN: 0385-5414

Volume

Issue

Page Numbers

55-71

Web of Science Id

WOS:000174066400008

Abstract

2,3,5-Substituted furo[2,3-b]pyridine was synthesised by palladium-catalyzed reaction of 5-bromo-2-hydroxy-3-iodopyridine and phenylacetylene with (Ph3P)(2)PdCI2, CuI in Et3N. A carbonylative cyclization of 5-hydroxy-2-methoxy-4-(2-phenylethynyl)pyridine with carbon monoxide in methanol with PdCI2, CuCI2 under basic conditions, has been accomplished to prepare methyl 2,5-substituted furo[2,3-c]pyridine-3-carboxylate.