1 : 1 molecular complexes of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (sulfamethazine) with indole-2-carboxylic acid and 2,4-dinitrobenzoic acid | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

1173108

Reference Type

Journal Article

Title

1 : 1 molecular complexes of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (sulfamethazine) with indole-2-carboxylic acid and 2,4-dinitrobenzoic acid

Author(s)

Lynch, DE; Sandhu, P; Parsons, S

Year

2000

Is Peer Reviewed?

Yes

Journal

Australian Journal of Chemistry
ISSN: 0004-9425
EISSN: 1445-0038

Volume

Issue

Page Numbers

383-387

Language

English

DOI

10.1071/ch00021

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0442279580&doi=10.1071%2fch00021&partnerID=40&md5=42a8549ea0542547165c68ed3acf39f5
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Abstract

The 1 : 1 molecular adducts of 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide (Sulfamethazine) with respectively indole-2-carboxylic acid (1) and 2,4-dinitrobenzoic acid (2) have been prepared and their X-ray crystal structures determined. The acid groups in both structures form associative R22(8) graph set hydrogen-bonding interactions across the N(11)-H/N(17) site of Sulfamethazine. A comparison of the two distances between relevant non-hydrogen atoms in this configuration reveals that this association is not symmetrical. An average difference of 0.144 Å is observed for seven listed complexes of Sulfamethazine, five having been previously reported. This average difference compares with a value of 0.265 Å for the same interaction seen in carboxylic acid adducts of 2-aminopyrimidine. © CSIRO 2000.

Keywords

sulfamethazine; carboxylic acid adducts; X-ray crystal structure