A continuous-flow O-methylation of phenols with dimethyl carbonate in a continuously fed stirred tank reactor | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

1179799

Reference Type

Journal Article

Title

A continuous-flow O-methylation of phenols with dimethyl carbonate in a continuously fed stirred tank reactor

Author(s)

Bomben, A; Selva, M; Pietro, T; Valli, L

Year

1999

Is Peer Reviewed?

Yes

Journal

Industrial and Engineering Chemistry Research
ISSN: 0888-5885
EISSN: 1520-5045

Volume

Issue

Page Numbers

2075-2079

DOI

10.1021/ie9806444

Web of Science Id

WOS:000080195000039

Abstract

A new continuous-flow methodology is reported far the selective O-methylation of phenol and p-cresol by using dimethyl carbonate as the methylating agent. The reaction has been performed by a continuously fed stirred tank reactor filled with a catalytic bed of poly(ethylene glycol) 1000 and K2CO3 as a base. Thus, operating at atmospheric pressure and at temperatures of 160-200 degrees C, the phenols have been transformed into their corresponding O-methylated derivatives (anisole and p-methylanisole, respectively) with substantially quantitative yields: under gradientless conditions, a space velocity of up to 9 x 10(-2) h(-1) was achieved.