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1180661 
Journal Article 
Classification of antidotes: practical considerations. Part II 
Lapostolle, E; Bismuth, C; Baud, F 
1999 
1 
La Semaine des Hôpitaux
ISSN: 0037-1777 
75 
3-4 
108-114 
WOS:000078527500009 
TABLE OF CONTENTS:



1) Introduction



2) Antidotes with toxicokinetic effects



Antidotes that restrict bioavailability of the poison: activated charcoal; others...



Antidotes that enhance elimination of the unchanged poison



By the lungs: oxygen in acute carbon monoxide poisoning; By the kidneys; deferoxamine in acute iron poisoning



Antidotes that activate metabolic pathways responsible for inactivation of the poison



N-acetylcysteine in acute acetaminophen poisoning, methylene blue in toxic methemoglobinemia - Antidotes that inhibit metabolic pathways responsible for activation of the poison: ethanol or 4-methyl-pyrazole in acute methanol or ethylene glycol poisoning



Antidotes that modify distribution of the poison in the body: thiosulfate, dicobalt EDTA, and cobalamine in acute cyanide poisoning



Fab fragment antibodies in acute digitalis poisoning,



3) Antidotes with toxicodynamic effects



Antidotes that displace the poison from its target: flumazenil in acute benzodiazepine poisoning, naloxone in acute opiate poisoning



Antidotes that bypass the poison-receptor link glucagon in acute beta-adrenoceptor antagonist poisoning. 
poisoning; antidotes 
• Methanol (Non-Cancer)
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