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1181664 
Journal Article 
SYNTHESIS OF 1-AMINOCYCLOPROPANOL BY ANODIC-OXIDATION 
Kienzler, T; Strazewski, P; Tamm, C 
1991 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
Georg Thieme Verlag 
1991 
10 
737-738 
English 
WOS:A1991GQ65400026 
The decarboxylation of 2-(tert-butoxycarbonylamino)isobutyric acid (2) by anodic oxidation in methanol or ethanol gives the corresponding tert-butyl N-(1-alkoxy-1-methylethyl)carbamates 3. The decarboxylation of 1-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid offers a new and efficient synthesis of tert-butyl N-(1-ethoxycyclopropyl)carbamate. Hydrolysis with acid yields the hydrochloride of 1-aminocyclopropanol, a potent enzyme inhibitor. © 1991 Georg Thieme Verlag. All rights reserved. 
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