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1185053 
Journal Article 
Solubility behaviour of carbamazepine in binary solvents: Extended Hildebrand solubility approach to obtain solubility and other parameters 
Subrahmanyam, CVS; Sarasija, S 
1997 
Yes 
Die Pharmazie
ISSN: 0031-7144 
Pharmazie 
52 
12 
939-942 
English 
WOS:000071203600008 
Abstract: The solubility of carbamazepine was obtained in binary mixtures of dioxane-water and a second SOLVENT* series consisting of ethylacetate/methanol and methanol/water systems. The analysis of data indicated that the solubility in dioxane/water follows nonregular solution behaviour, while in the second SOLVENT* series, it is nearly regular. Besides predicting the level of solubility of drugs, an extended Hildebrand solubility approach (EHS) should be able to predict the solubility parameter, delta(2), of the drugs. In this study, the delta(2)-value of carbamazepine was determined by an EHS approach and compared with the values obtained by other methods. All methods agree with each other and the delta(2) value of carbamazepine is 10.675 H. ds: Pharmacology & Pharmacy cument Delivery No.: YN758 e field[29]: 1,4-Dioxane 
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