COLORED COMPLEXES OF ALL-TRANS-RETINAL WITH BENZOCAINE AND OTHER LOCAL-ANESTHETICS | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1198868

Reference Type

Journal Article

Title

COLORED COMPLEXES OF ALL-TRANS-RETINAL WITH BENZOCAINE AND OTHER LOCAL-ANESTHETICS

Author(s)

Fowler, GJS; Devonshire, R

Year

1991

Is Peer Reviewed?

Journal

Journal of Photochemistry and Photobiology B: Biology
ISSN: 1011-1344
EISSN: 1873-2682

Volume

Issue

Page Numbers

183-188

Language

English

PMID

1904919

DOI

10.1016/1011-1344(91)80057-O

Web of Science Id

WOS:A1991ET93100005

Abstract

Coloured Schiff base complexes with lambda max values of 500 nm or above were formed between the visual pigment all-trans-retinal and the local anesthetics procaine (lambda max = 533 nm), benzocaine (4-amino-benzoic acid ethyl ester, lambda max = 535 nm), 3-amino-benzoic acid ethyl ester (lambda max = 500 nm) and 2-amino-benzoic acid ethyl ester (lambda max = 509 nm) in methanol acidified with HCl. The anaesthetics lidocaine and urethane failed to form coloured compounds with lambda max values greater than 500 nm under the same conditions. The relevance of these observations to the effect of anaesthetics on the visual pigments is discussed.

Keywords

RETINALDEHYDE; RETINAL; LOCAL ANESTHETIC; BENZOCAINE; PROCAINE; SCHIFF BASE