US EPA

1231056 

Journal Article 

[Effects of chromium compounds to the respiratory system: Part 1. An experimental study of inhalation of chromic acid mist in electroplating] 

Adachi, S; Yoshimura, H; Miyayama, R; Katayama, H; Takemoto, K; Kawai, H 

1981 

0 

Sangyo Igaku/Japanese Journal of Industrial Health (Japan)
ISSN: 0047-1879
EISSN: 1881-1302 

23 

3 

294-299 

Japanese 

7277851 

10.1539/joh1959.23.294 

is related to other part(s) 013979 [Effects of chromium compounds on the respiratory system: Part 4. Long term inhalation of chromic acid mist in electroplating to ICR female mice]
is related to other part(s) 1231007 [Effects of chromium compounds on the respiratory system: Part 5. Long term inhalation of chromic acid mist in electroplating by C57BL female mice and recapitulation of our experimental studies]
is related to other part(s) 1231038 [Effects of chromium compounds on the respiratory system: Part 2. Difference between water-soluble hexavalent and trivalent compounds]
is related to other part(s) 1236953 [Effects of chromium compounds on the respiratory system (Part 3) Inhalation of chromic oxide (Cr2O3) dust by F344 rats]

Chromium concentrations in the lungs, liver and kidneys of rats (Sprague-Dawley, female) after single inhalation or long-term inhalation of chromic acid mist in electroplating were examined by flameless atomic absorption spectrometry. I) Long-term inhalation: Rats inhaled the mist twice a week for 6 months (30 min for single inhalation, average chromium concentration in the inhalation chamber was 3.18 mgCr/m), and remained uninhaled for the following 6 months. Chromium content in the lungs of rats inhaled for 3 months was 30.533 μg, 35.000 μg in those for 6 months, but 15.600 μg in those inhaled for the first 6 months and remained uninhaled for the following 6 months. These values were extremely higher than that of the control (0.201 μg). Chromium hexavalent chromic acid, in the mist, is supposed to be reduced to trivalent state and produce and insoluble compound. Chromium in the lungs of rats remained uninhaled for 6 months may take the form of such an insoluble compound. Chromium concentration in the liver and kidneys of rats after long-term inhalation was much higher than those of the control and so was that of the following 6-month uninhalation. II) Single inhalation: Chromium contents in the lungs of rats after single inhalation decreased as time passed and the curve of decrease showed an exponential form. Biological half time of the chromium content in the lungs was 120 hours. Chromium concentrations in the liver and kidneys of rats immediately after the single inhalation were already higher than those of the control. A part of the inhaled chromium mist is supposed to be transferred into the blood stream through the lungs. Concerning the long-term inhalation of chromic acid mist in the electroplating, chromium in the lungs, liver and kidneys was retained for a long time in spite of remaining uninhaled for 6 months. In the single inhalation, chromium contents in the lungs were almost decreased to that of the control within 4 weeks. According to these results, it suggests that there was certain histological or chemical changes in the lungs of chromium itself in the mist.