US EPA

1231274 

Book/Book Chapter 

Isopropyl Alcohol 

Park, JG; Beamer, CM 

1953 

Wiley Interscience 

New York, NY 

NIOSH/00063137 

Encyclopedia of chemical technology 

11 

182-190 

has other version or edition 1935950 Isopropyl Alcohol

Physical, chemical, and toxicological properties of isopropyl-alcohol (67630) are discussed. Isopropyl-alcohol is completely miscible with water (7732185) and all common hydrocarbon and oxygenated solvents. It forms a constant boiling mixture with water, containing 91.32 percent by volume of the alcohol. Several constant boiling ternary mixtures containing isopropyl-alcohol are known, and some of these are tabulated. In its chemical behavior, isopropyl-alcohol is similar in many respects to other alcohols, particularly the lower molecular weight monohydroxy alcohols. The dehydration of isopropyl-alcohol takes place when it is heated with sulfuric-acid (7664939), phosphoric-acid (7664382), or benzenesulfonic-acid (98113) at the proper concentrations under suitable conditions. The products of this reaction are isopropyl-ether and propylene (115071). In the oxidation of isopropyl-alcohol, acetone (67641), is formed first and further oxidation yields carbon-dioxide (124389), oxalic-acid (144627), and acetic-acid (64197). Chromic-acid (1333820), under carefully controlled conditions, is used for the quantitative determination of isopropyl-alcohol in mixtures. The manufacture of isopropyl-alcohol is discussed, along with economic aspects of the alcohol in commerce. In terms of toxicological properties, isopropyl-alcohol if taken internally is absorbed rapidly from the gastrointestinal tract and diffuses into the tissues. Extensive experiments with rats, rabbits, and dogs have shown that the toxicity of isopropyl-alcohol is somewhat greater than that of ethyl-alcohol (64175), although no evidence of skin irritation or absorption has been reported. Isopropyl-alcohol has been given clinically in concentrations equivalent to 15 ml of pure alcohol for several days with no harmful effects. Uses of isopropyl-alcohol and procedures for its shipping and handling are reported. 

DCN-155142; Chemistry; Toxicology; Absorption; Manufacturing 

1st