Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1236306
Reference Type
Journal Article
Title
Rejection of metal to metal prosthesis and skin sensitivity to cobalt
Author(s)
Munro-Ashman, D; Miller, AJ
Year
1976
Is Peer Reviewed?
Yes
Journal
Contact Dermatitis
ISSN:
0105-1873
EISSN:
1600-0536
Report Number
NIOSH/00136609
Volume
2
Issue
2
Page Numbers
65-67
Language
English
PMID
1017180
Abstract
Metal to metal prostheses give satisfactory results in 90% of patients. About half of the failure rate may be due to allergic reaction to the metals involved, particularly cobalt. A total of 35 patients in this unsatisfactory group have been patch-tested; 16 were positive to metals, 13 to cobalt, 4 to nickel, and 2 to chromate. Only two patients showed any skin lesions - one a localized dermatitis round the knee joint from nickel sensitivity, and one to cobalt who had a widespread scattered circular erythematous lesion suggestive of a generalized allergic vasculitis. Patients requiring a metal/metal prosthesis should have a careful history taken for metal sensitivity and be patch-tested with the metals. All the patients in this investigation had metal/metal prostheses and no reaction was seen after metal/high density polyethylene implants. Titanium 318 may be a satisfactory substitute for cobalt chrome alloy if reactions are encountered.
Keywords
DCN-124766
;
Clinical symptoms
;
Skin tests
;
Biological effects
;
Toxic effects
;
Dermatology
;
Skin exposure
;
Clinical diagnosis
;
Physiological response
;
Biological factors
Tags
IRIS
•
Chromium VI
Considered
Potentially Relevant Supplemental Material
Dermal Studies
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity