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HERO ID
1238487
Reference Type
Technical Report
Title
Strontium Chromate
Author(s)
Anonymous
Year
2001
Report Number
RISKLINE/2003060041
Volume
Documentation of the threshold limit values and biological exposure indices
Vol
Issue
2001
Language
English
Abstract
A TLV-TWA of 0.0005 mg/m3, measured as chromium (Cr), is recommended for occupational exposure to strontium chromate. No published epidemiological or clinical studies of workers exposed to strontium chromate were identified in the open scientific or medical literature. However, long-term oncogenic studies with rodents resulted in statistically significant numbers of implantation-site tumors, including up to a 62% incidence of bronchial carcinomas compared with 0% in pellet-vehicle control animals. Furthermore, strontium chromate is of greater potency for tumorigenesis when compared to the reference carcinogens calcium chromate and methylcholanthrene. For these reasons, an A2, Suspected Human Carcinogen, notation is justified. In addition, for A2 carcinogens with a TLV, worker exposure by all routes should be carefully controlled to levels as low as possible below the TLV. Sufficient data were not available to recommend Skin or SEN notations or a TLV-STEL.
Keywords
ANIMAL
;
acute toxicity
;
carcinogenicity
;
carcinogens
;
mammary gland
;
nervous system
;
respiratory system
;
HUMAN
Tags
IRIS
•
Chromium VI
Considered
Excluded
Other Cr Compounds
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