Health & Environmental Research Online (HERO)


Print Feedback Export to File
1238487 
Technical Report 
Strontium Chromate 
Anonymous 
2001 
RISKLINE/2003060041 
Documentation of the threshold limit values and biological exposure indices
Vol 
2001 
English 
A TLV-TWA of 0.0005 mg/m3, measured as chromium (Cr), is recommended for occupational exposure to strontium chromate. No published epidemiological or clinical studies of workers exposed to strontium chromate were identified in the open scientific or medical literature. However, long-term oncogenic studies with rodents resulted in statistically significant numbers of implantation-site tumors, including up to a 62% incidence of bronchial carcinomas compared with 0% in pellet-vehicle control animals. Furthermore, strontium chromate is of greater potency for tumorigenesis when compared to the reference carcinogens calcium chromate and methylcholanthrene. For these reasons, an A2, Suspected Human Carcinogen, notation is justified. In addition, for A2 carcinogens with a TLV, worker exposure by all routes should be carefully controlled to levels as low as possible below the TLV. Sufficient data were not available to recommend Skin or SEN notations or a TLV-STEL. 
ANIMAL; acute toxicity; carcinogenicity; carcinogens; mammary gland; nervous system; respiratory system; HUMAN 
IRIS
• Chromium VI
     Considered
          Excluded
               Other Cr Compounds