C-H functionalization of tertiary amines by cross dehydrogenative coupling reactions: solvent-free synthesis of α-aminonitriles and β-nitroamines under aerobic condition | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

1256786

Reference Type

Journal Article

Title

C-H functionalization of tertiary amines by cross dehydrogenative coupling reactions: solvent-free synthesis of α-aminonitriles and β-nitroamines under aerobic condition

Author(s)

Alagiri, K; Prabhu, KR

Year

2012

Is Peer Reviewed?

Journal

Organic and Biomolecular Chemistry
ISSN: 1477-0520
EISSN: 1477-0539

Volume

Issue

Page Numbers

835-842

Language

English

PMID

22130687

DOI

10.1039/c1ob06466e

Web of Science Id

WOS:000298751900020

Abstract

A solvent-free synthesis of α-aminonitriles and β-nitroamines by oxidative cross-dehydrogenative coupling under aerobic condition is reported. A catalytic amount of molybdenum(vi) acetylacetonoate was found to catalyze cyanation of tertiary amines to form α-aminonitriles, whereas vanadium pentoxide was found to promote aza-Henry reaction to furnish β-nitroamines. Both of these environmentally benign reactions are performed in the absence of solvents using molecular oxygen as an oxidant.