Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1258233
Reference Type
Journal Article
Title
Protective Effects of Pine Bark Extract on Hexavalent Chromium-Induced Dermatotoxicity in Rats
Author(s)
Lee, IC; Kim, SH; Shin, IS; Moon, C; Park, SH; Kim, SH; Park, SC; Kim, HC; Kim, JC
Year
2012
Is Peer Reviewed?
1
Journal
Phytotherapy Research
ISSN:
0951-418X
EISSN:
1099-1573
Volume
26
Issue
10
Page Numbers
1534-1540
Language
English
PMID
22344852
DOI
10.1002/ptr.4610
Abstract
The present study investigated the protective effects of pine bark extract (PBE) against hexavalent chromium [Cr(VI)]-induced dermatotoxicity in rats. Skin reactions were evaluated by visual inspection, histopathological changes and oxidative stress parameters. Topical application of Cr(VI) produced a significant increase in the incidence and severity of erythema and edema upon visual inspection. Histopathological examination showed moderate to severe necrosis and desquamation in the epidermis and inflammation and hemorrhage in the dermis. In addition, an increased malondialdehyde (MDA) concentration, and decreased glutathione (GSH), catalase, superoxide dismutase, glutathione-S-transferase (GST) and glutathione reductase of the skin were observed in the Cr(VI) group. On the contrary, concomitant administration with PBE significantly improved Cr(VI)-induced dermatotoxicity, evidenced by a decrease in the incidence and severity of skin irritation and histopathological lesions in a dose-dependent manner. Moreover, PBE treatment reduced MDA concentrations and increased catalase and GST activities in skin tissues, indicating that concomitant administration with PBE effectively prevents Cr(VI)-induced oxidative damage in rats. The results indicate that PBE has a protective effect against Cr(VI)-induced dermatotoxicity and is useful as a protective agent against various dermal lesions induced by oxidative stress. Copyright © 2012 John Wiley & Sons, Ltd.
Tags
IRIS
•
Chromium VI
Considered
Potentially Relevant Supplemental Material
Dermal Studies
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity