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HERO ID
1279609
Reference Type
Journal Article
Subtype
Review
Title
Nanoparticle dermal absorption and toxicity: a review of the literature
Author(s)
Crosera, M; Bovenzi, M; Maina, G; Adami, G; Zanette, C; Florio, C; Filon Larese, F
Year
2009
Is Peer Reviewed?
Yes
Journal
International Archives of Occupational and Environmental Health
ISSN:
0340-0131
EISSN:
1432-1246
Publisher
Springer Science+Business Media
Report Number
CIS/09/01295
Volume
82
Issue
9 (Oct 2009)
Page Numbers
1043-1055
Language
English
PMID
19705142
DOI
10.1007/s00420-009-0458-x
Web of Science Id
WOS:000270736700001
Abstract
Introduction: Nanotechnologies are among the fastest growing areas of scientific research and have important applications in a wide variety of fields. The data suggest that in the future workers and consumers exposed to nanoparticles will significantly increase. Dermal absorption and toxicity of nanoparticles: At now there are gaps in understanding about the human and environmental risk that manufactured nanoparticles pose for occupational exposed people and for consumers. There is a need for assessing the health and environmental impacts, the nanoparticles life cycle, the human exposure routes, the behavior of nanoparticles in the body, and the risk for workers. Possible routes of entry into the body include inhalation, absorption through the skin or digestive tract, injection, and absorption or implantation for drugs delivery systems. In particular, dermal absorption and skin penetration of nanoparticles needs a better evaluation because few and contradictory data are present in the literature, mainly on titanium dioxide. Conclusions: There are limited data on carbon-based nanoparticles and very few data on other metal nanoparticles increasingly used in industry. The article reviews the literature on the percutaneous absorption of nanoparticles and their effect on skin.
Keywords
Skin absorption; Nanoparticles; Review
Tags
•
Nanoscale Carbon
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