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1322754 
Journal Article 
Structure‐activity relationships for skin sensitisation potential of diacrylates and dimethacrylates 
Roberts, DW 
1987 
Yes 
Contact Dermatitis
ISSN: 0105-1873
EISSN: 1600-0536 
17 
5 
281-289 
English 
3436133 
WOS:A1987L291000004 
Apparently conflicting guinea pig sensitisation data on diacrylates and dimethacrylates published by 3 groups of authors, are analysed in terms of the RAJ model. This model, correlating sesitisation score with a combination of induction dose, chemical reactivity and lipophilicity, enables the major discrepancies to be rationalised. The data provide a striking example of the overload effect, in that some of the diacrylates have failed to show sensitisation when tested at high induction doses, but are revealed as strong sensitisers when tested by other authors at lower induction doses. 
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