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HERO ID
1344659
Reference Type
Book/Book Chapter
Title
GARLIC: A PROMISING ANTIDOTE TO HEAVY METAL TOXICITY
Author(s)
Chowdhury, R; Chaudhuri, K
Year
2010
Book Title
Food and Beverage Consumption and Health
Page Numbers
215-230
Web of Science Id
WOS:000281529900007
Abstract
Garlic for centuries has been well known for its medicinal
attributes in addition to its other virtues. Garlic in different forms has antioxidant
properties. These properties are shown to be due to the existence of compounds such as water
soluble organosulfur compounds, S-allylcysteine and lipid soluble compounds like diallyl sulfide.
It shows phenomenal ameliorating properties against heavy metal poisoning due to its possession
of chemicals containing organo-sulfur groups, volatile oils, enzymes, carbohydrates and amino
acids. With the threat of heavy metal poisoning increasing every day and lead, mercury, cadmium,
arsenic, and copper poisoning gradually attaining alarming proportions, garlic was extensively
exploited to treat the metal-induced toxicities. Recent supportive evidences indicate that garlic
contain compounds capable of detoxifying lead, cadmium, methlymercury, phenylmercury and arsenic
The restorative property of garlic was attributed to its antioxidant activity and/or chelating
efficacy. The clastogenic effects of the heavy metals were also pronouncedly reduced by dietary
administration of garlic Fatal effects with respect to body metal burden, oxidative stress and
mitochondrial injury were effectively reduced by garlic The curative effect of garlic was
superior to those of 2,3-dimercapto-1-propanol (BAL) and D-penicillamine(PEN), 2,3-
dimercaptosuccinic acid (DMSA) and N-acetyl-DL-penicillamine (APEN), and the current remedies. In
this commentary, the research advances on the chemistry and pharmacology of garlic and the
potential and molecular mechanism of garlic mediated attenuation of heavy metal toxicity are
discussed.
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Arsenic Hazard ID
1. Initial Lit Search
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4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
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Arsenic (Inorganic)
1. Literature
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