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1351556 
Journal Article 
AN IMPROVED SYNTHESIS OF DIHYDROXYACETONE PHOSPHATE 
Pederson, RL; Esker, J; Wong, CH 
1991 
1 
Tetrahedron
ISSN: 0040-4020 
Elsevier 
Tetrahedron 
47 
14-15 
2643-2648 
WOS:A1991FB16500025 
Abstract: An improved procedure has been developed for the synthesis of dihydroxyacetone phosphate (DHAP). Reaction of 2,5-diethoxy-p-dioxane-2,5-dimethanol (1) and the trivalent phosphorylating reagent dibenzyl-N,N-diethylphosphoramidite (DDP) in the presence of 1,2,4-triazole or tetrazole followed by oxidation with H2O2 gave 2,5-diethoxy-p-dioxane-2,5-dimethanol-O-21-O-51- bis(phosphate) tetrabenzyl ester (2) in 98% yield. Compound 2 was then hydrogenated in the presence of H2-Pd/C to give, after neutralization, 2,5-diethoxy-p-dioxane-2,5-dimethanol-O-21-O-51-bis(phosphate) as a stable trisodium salt (3) in 84% yield. Treatment of 3 with Dowex 50 (H+) generates 2 equivalents of DHAP. e field[29]: 1,4-Dioxane