US EPA

1421012 

Journal Article 

The effects of repeated parenteral administration of chelating agents on the distribution and excretion of uranium 

Domingo, JL; Ortega, A; Llobet, JM; Paternain, JL; Corbella, J 

1989 

1 

Research Communications in Chemical Pathology and Pharmacology
ISSN: 0034-5164 

NIOSH/00188139 

64 

1 

161-164 

English 

2748997 

The effects of repeated ip administration of gallic acid, 4,5-dihydroxy-1,3-benzenedisulfonic acid (Tiron), diethylenetriaminepentaacetic acid (DTPA), and 5-aminosalicylic acid (5-AS) on the distribution and excretion of uranium were assessed in male Swiss mice. Only Tiron significantly increased the amount of uranium excreted into urine and feces. A significant decrease in the concentration of uranium in liver, spleen and bone was observed after administration of Tiron, whereas injection of gallic acid or DTPA resulted in a significant decrease in the concentration of the metal in the liver. The results show that Tiron was consistently the most effective chelator of those tested in the treatment of uranium poisoning after repeated daily administration of the metal. 

DCN-183575; Chelating agents; Uranium compounds; Metallic poisoning; Metabolic study; Drug therapy; Excretion; Laboratory animals; Radionuclides