Cancer of the lung: the cytology of sputum prior to the development of carcinoma | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

1421370

Reference Type

Journal Article

Title

Cancer of the lung: the cytology of sputum prior to the development of carcinoma

Author(s)

Saccomanno, G; Saunders, RP; Archer, VE; Auerbach, O; Kuschner, M; Beckler, PA

Year

1965

Is Peer Reviewed?

Yes

Journal

Acta Cytologica
ISSN: 0001-5547

Report Number

NIOSH/00127654

Volume

Issue

Page Numbers

413-423

Language

English

PMID

5218351

Abstract

Precancerous changes in sputum cytology were investigated in humans. Sputum samples were taken from 24 uranium miners who subsequently developed lung cancer. Samples were examined microscopically for cell abnormalities. Varying degrees of metaplasia were seen. Cell appearance became progressively more abnormal as the patient came closer to cancer diagnosis. Similarities were noted between the structure of the abnormal cells and the type of tumor that finally developed. The authors conclude that sputum cytology is a good way to detect precancerous changes in high risk groups.

Keywords

DCN-116098; Cytopathology; Cellular structures; Cell biology; Clinical tests; Mining industry; Diagnostic techniques; Diagnostic tests; Cytology