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14338 
Journal Article 
The effects of sodium chromate on the proximal tubules of the rat kidney: fine structural damage and lysozymuria 
Evan, AP; Dail, WG, Jr 
1974 
1 
Laboratory Investigation
ISSN: 0023-6837
EISSN: 1530-0307 
HEEP/75/00585* 
30 
6 
704-715 
English 
4365167 
HEEP COPYRIGHT: BIOL ABS. Sodium chromate (10 or 20 mg/kg i.p.) induces structural changes which appear to be correlated with the amount of lysoz-me in the urine. Chromate selectively affects the cells of the convoluted portion of the proximal tubule. The sequence of progressive changes leading to nephron damage are: swelling and loss of microvilli; formation of intracellular vacuoles of varied sizes; mitochondrial swelling; and cytoplasmic liquefaction followed by desquamation. Tubular damage is greater at higher dose levels and at longer time intervals. The amount of lysozyme in the urine increases as damage to the proximal tubule cells becomes more pronounced, suggesting that urinary lysozyme activity may be a good indicator of severe proximal tubular damage. 
IRIS
• Chromium VI
     Considered
          Potentially Relevant Supplemental Material
               Injection/Intratracheal Studies