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HERO ID
1508481
Reference Type
Journal Article
Title
Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase
Author(s)
Siu, MT; Wiley, MJ; Wells, PG
Year
2013
Is Peer Reviewed?
1
Journal
Reproductive Toxicology
ISSN:
0890-6238
EISSN:
1873-1708
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
36
Page Numbers
33-39
Language
English
PMID
23207165
DOI
10.1016/j.reprotox.2012.11.006
Web of Science Id
WOS:000316307000006
Abstract
The role of catalase in methanol (MeOH) teratogenesis is unclear. In rodents it both detoxifies reactive oxygen species (ROS) and metabolizes MeOH and its formic acid (FA) metabolite. We treated pregnant mice expressing either high (hCat) or low catalase activity (aCat), or their wild-type (WT) controls, with either MeOH (4g/kg ip) or saline. hCat mice and WTs were similarly susceptible to MeOH-initiated ophthalmic abnormalities and cleft palates. aCat and WT mice appeared resistant, precluding assessment of the developmental impact of catalase deficiency. Catalase activity was respectively increased at least 1.5-fold, and decreased by at least 35%, in hCat and aCat embryos and maternal livers. MeOH and FA pharmacokinetic profiles were similar among hCat, aCat and WT strains. Although the hCat results imply no ROS involvement, embryo culture studies suggest this may be confounded by maternal factors and/or a requirement for higher catalase activity in the hCat mice.
Tags
IRIS
•
Formaldehyde
Exposure Litsearch Jan 2012 - Aug 2015
PubMed
Human exposure to formaldehyde
•
Methanol (Non-Cancer)
Cited in Final (2013)
Cited in External Review Draft (2013)
Cited in External Review Draft (2011)
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