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HERO ID
1520151
Reference Type
Journal Article
Title
Evaluation of the effects of ozone therapy on Escherichia coli-induced cytitis in rat
Author(s)
Tasdemir, C; Tasdemir, S; Vardi, N; Ates, B; Onal, Y; Erdogan, S; Yucel, A; Aglamis, E; Yakupogullari, Y; Altıntas, R; Karaman, A
Year
2013
Is Peer Reviewed?
Yes
Journal
Irish Journal of Medical Science
ISSN:
0021-1265
Volume
182
Issue
4
Page Numbers
557-563
Language
English
PMID
23456133
DOI
10.1007/s11845-013-0926-x
Web of Science Id
WOS:000325827100005
Abstract
OBJECTIVES: The aim of the study was to investigate the effect of ozone on oxidative/nitrosative stress and bladder injury caused by Escherichia coli in rat bladder. METHODS: Twenty-one Wistar-Albino-type female rats included in the study were divided into three groups of equal number: (1) sham operation (control), (2) E. coli-only (EC), (3) EC + ozone. After ozone therapy for 3 days, urine and tissue samples were obtained for biochemical, microbiological, and histopathological analysis. RESULTS: Tissue malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) level were increased, whereas superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity was decreased in the EC group. MDA, MPO, and NO levels were decreased, whereas SOD, GPx activity was increased in the ozone-treated group. Also, there was no bacterial translocation in this group. CONCLUSION: The results of the present study suggest that ozone may be used as an agent to protect the bladder from oxidative/nitrosative stress occurring in cystitis.
Keywords
Ozone; Cystitis; Rats; Oxidative stress
Tags
NAAQS
•
ISA-Ozone (2020 Final Project Page)
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