The Cosmetic Ingredient Review (CIR) program Expert Panel has assessed the safety of almost 1300 cosmetic ingredi-ents since its inception in 1976. These safety assessments were published in the Journal of Environmental Pathology and Toxicology in 1980, the Journal of the American College of Toxicology, from 1982 to 1996, and since then in the International Journal of Toxicology. Because information relevant to the safety of ingredients may have become available since early safety assessments were pub-lished, the CIR Expert Panel has initiated a re-review process. If new information is thought to be available or if a long period of time has passed, the CIR Expert Panel may initiate a search for relevant new data. In some cases, newly available data are largely redundant with the data available in the original safety assessment. In other cases, there are new safety data. If the CIR Expert Panel decides to not reopen a safety assessment, this finding is summarized and announced publicly. To assure that the scientific community is aware of any new information and the decision to not reopen, this Annual Review of Cosmetic Ingredient Safety Assessments is prepared. A reference list is provided that updates the available pub-lished literature and includes any unpublished data made avail-able since the original safety assessment. The re-review also captures information on the industry's current practices of ingredient use, updating the data available in the earlier report. Although this material provides the opinion of the CIR Expert Panel regarding the new data described, it does not constitute a full safety review. The ingredients the CIR Expert Panel reconsidered in 2004/2005, and decided not to reopen are: Benzethonium Chloride and Methylbenzethonium Chloride; 2-Bromo-2-Nitropropane-1,3-Diol; Butylated Hydroxyanisole (BHA); Butylene Glycol; Hexylene Glycol; Ethoxydiglycol, and Dipropylene Glycol; Cetearyl Octanoate (Ceteraryl Ethylhexanoate); Cholesterol; Chloroxylenol; Diisopropanolamine, Isopropanolamine, Triisopropanolamine, and Mixed Isopropanolammes; Dioctyl Adipate and Diisopropyl Adipate Formaldehyde; Hydrolyzed Collagen; p-Hydroxyanisole; Isostearyl Neopentanoate; 2-Nitro-p-Phenylenediamine and 4-Nitro-o-Phenylenediamine Oleic Acid; Lauric Aci; Palmitic Acid, Myristic Acid, Stearic Acid; Panthenol and Pantothenic Acid: p-Phenylenediamine; Phenyl Trimethicone; Propylene Carbonate; Propyl Gallate;Polyvinylpyrrolidone/Vinyl Acetate Copolymer; Safflower Oil; Sodium Borate and Boric Acid; Sodium Dehydroacetate and Dehydroacetic Acid; Sodium Lauryl Sulfoacetate; Sodium Sesquicarbonate, Sodium Bicarbonate, and Sodium Carbonate; Stearyl.Alcohol, Oleyl Alcohol, and Octyl Dodecanol; Toluene; Toluenesulfonamide/Formaldehyde Resin; Tragacanth Gum; Vinyl Acetate/Crotonic Acid Copolymer; Zinc Phenolsulfonate.