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Citation
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HERO ID
191988
Reference Type
Journal Article
Title
Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
Author(s)
Tamagawa, E; Bai, N; Morimoto, K; Gray, C; Mui, T; Yatera, K; Zhang, X; Xing, L; Li, Y; Laher, I
Year
2008
Is Peer Reviewed?
Yes
Journal
American Journal of Physiology: Lung Cellular and Molecular Physiology
ISSN:
1040-0605
EISSN:
1522-1504
Volume
295
Issue
1
Page Numbers
L79-L85
Language
English
PMID
18469117
DOI
10.1152/ajplung.00048.2007
Web of Science Id
WOS:000257335900010
Abstract
Epidemiologic and animal studies have shown that exposure to particulate matter air pollution (PM) is a risk factor for the development of atherosclerosis. Whether PM-induced lung and systemic inflammation is involved in this process is not clear. We hypothesized that PM exposure causes lung and systemic inflammation, which in turn leads to vascular endothelial dysfunction, a key step in the initiation and progression of atherosclerosis. New Zealand White rabbits were exposed for 5 days (acute, total dose 8 mg) and 4 wk (chronic, total dose 16 mg) to either PM smaller than 10 mum (PM(10)) or saline intratracheally. Lung inflammation was quantified by morphometry; systemic inflammation was assessed by white blood cell and platelet counts and serum interleukin (IL)-6, nitric oxide, and endothelin levels. Endothelial dysfunction was assessed by vascular response to acetylcholine (ACh) and sodium nitroprusside (SNP). PM(10) exposure increased lung macrophages (P<0.02), macrophages containing particles (P<0.001), and activated macrophages (P<0.006). PM(10) increased serum IL-6 levels in the first 2 wk of exposure (P<0.05) but not in weeks 3 or 4. PM(10) exposure reduced ACh-related relaxation of the carotid artery with both acute and chronic exposure, with no effect on SNP-induced vasodilatation. Serum IL-6 levels correlated with macrophages containing particles (P=0.043) and ACh-induced vasodilatation (P=0.014 at week 1, P=0.021 at week 2). Exposure to PM(10) caused lung and systemic inflammation that were both associated with vascular endothelial dysfunction. This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution.
Keywords
air pollution; alveolar macrophage; systemic inflammation; interleukin-6
Month
01
Tags
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ISA-PM (2009 Final Project Page)
2009 Final
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