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Citation
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HERO ID
1927749
Reference Type
Journal Article
Title
Comparative evaluation of liquid chromatography-mass spectrometry versus gas chromatography-mass spectrometry for the determination of hexabromocyclododecanes and their degradation products in indoor dust
Author(s)
Abdallah, MA; Ibarra, C; Neels, H; Harrad, S; Covaci, A
Year
2008
Is Peer Reviewed?
Yes
Journal
Journal of Chromatography A
ISSN:
0021-9673
EISSN:
1873-3778
Volume
1190
Issue
1-2
Page Numbers
333-341
Language
English
PMID
18359486
DOI
10.1016/j.chroma.2008.03.006
Web of Science Id
WOS:000255848600040
Abstract
Domestic and office dust samples (n=37) were analyzed for hexabromocyclododecanes (HBCDs) using gas chromatography-electron-capture negative ionization-mass spectrometry (GC-ECNI/MS) and liquid chromatography-electrospray tandem mass spectrometry (LC-ESI/MS/MS). To determine the best method to quantify HBCDs using GC-ECNI/MS, BDE 128 was used as internal standard (I.S.) in all samples, while 13C-labeled alpha-HBCD was used as I.S. in some samples. Total HBCD concentrations (sum of alpha-, beta-, and gamma-HBCD diastereomers) were calculated using response factors (RFs) for alpha- and gamma-HBCD as individual diastereomers and using an average RF for both diastereomers. Statistical comparison showed that concentrations obtained via GC-ECNI/MS were statistically indistinguishable (p>0.05) from those obtained using LC-ESI/MS/MS. The closest match between the two techniques was obtained using [13C]alpha-HBCD as I.S. and the average RF for alpha- and gamma-HBCDs. Excellent linear correlations (Pearson coefficient values r>0.9) were obtained between the GC-ECNI/MS and LC-ESI/MS/MS results, with slopes ranging from 0.76 to 1.36. Pentabromocyclododecenes (four isomers) and tetrabromocyclododecadienes (two isomers) were detected in the studied samples and were identified as degradation products of HBCDs after separation from the parent compound on the basis of both retention time and mass spectrum. This finding suggests that the elimination of HBr is the major degradation pathway for HBCDs in dust.
Keywords
liquid chromatography; gas chromatography; mass spectrometry; hexabromocyclododecanes; HBCDs; degradation products; indoor dust
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
Database Searches
Pubmed
Excluded/Not on Topic
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
Off topic
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