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Citation
Tags
HERO ID
1927821
Reference Type
Journal Article
Title
Effects of the brominated flame retardants hexabromocyclododecane (HBCDD), and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout
Author(s)
Ronisz, D; Finne, EF; Karlsson, H; Förlin, L
Year
2004
Is Peer Reviewed?
Yes
Journal
Aquatic Toxicology
ISSN:
0166-445X
EISSN:
1879-1514
Volume
69
Issue
3
Page Numbers
229-245
Language
English
PMID
15276329
DOI
10.1016/j.aquatox.2004.05.007
Web of Science Id
WOS:000223285400003
URL
https://www.proquest.com/scholarly-journals/effects-brominated-flame-retardants/docview/66743533/se-2?accountid=171501
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Abstract
Brominated flame retardants (BFRs) leak out in the environment, including the aquatic one. Despite this, sublethal effects of these chemicals are poorly investigated in fish. In this study, a screening of selected biomarkers in juvenile rainbow trout (Oncorhynchus mykiss) and feral eelpout (Zoarces viviparus) was performed after exposure to hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA). Rainbow trout was injected intraperitoneally (i.p.) with HBCDD or TBBPA. Two out of four short-term experiments with HBCDD showed an increase in the activity of catalase. A 40% increase in liver somatic index (LSI) could be observed after 28 days. HBCDD did also seem to have an inhibitory effect on CYP1A's activity (ethoxyresorufin-O-deethylase (EROD)). A putative peroxisome proliferating activity of the compound was investigated without giving a definite answer. HBCDD did not seem to be estrogenic or genotoxic. TBBPA increased the activity of glutathione reductase (GR) after 4, 14 and 28 days in rainbow trout suggesting a possible role of this compound in inducing oxidative stress. The compound did not seem to be estrogenic. TBBPA seemed to compete with the artificial substrate ethoxyresorufin in vitro, during the EROD assay. In eelpout, only one 5 days in vivo experiment was performed. Neither of the compounds gave rise to any effect in this fish. This was the first screening of sublethal effects of the two chemicals in fish, using high doses. Our results indicate that there is a need for further studies of long-term, low-dose effects of these two widely used flame retardants.
Keywords
brominated flame retardants; hexabromocyclododecane; tetrabromobisphenol A; biomarkers; fish
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
Database Searches
Pubmed
WOS
Sources of Mechanistic and Toxicokinetic Data
Mechanistic and genotoxicity studies
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
MOA
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