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195060 
Journal Article 
Results of mouse bone marrow micronucleus studies on 1,4-dioxane 
McFee, AF; Abbott, MG; Gulati, DK; Shelby, MD 
1994 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
322 
2 
145-148 
English 
7519323 
WOS:A1994PM07000010 
1,4-Dioxane (CAS No. 123-91-1) is widely used as a solvent in various commercial processes. It has shown indications of being a non-mutagenic carcinogen, and it is therefore of particular interest to further define its genotoxic characteristics. Male and female mice consuming water containing 0.5 or 1.0% 1,4-dioxane developed hepatic tumors (NCI, 1978), and other assays have verified its carcinogenicity in rodents (IARC, 1987; Ashby and Tennant, 1991). The compound has given negative results when tested for mutagenicity in Salmonella, as well as in sex-linked recessive lethal studies in Drosophila. We report here a series of trials in which the micronucleus-inducing ability of 1,4-dioxane was assessed in bone marrow cells of mice. 
1,4-dioxane; mouse; bone marrow; clastogenicity; micronuclei 
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