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195086 
Journal Article 
Activity of 1,4-dioxane in mouse bone marrow micronucleus assays 
Tinwell, H; Ashby, J 
1994 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
Mutation Research 
322 
2 
148-150 
English 
7519324 
WOS:A1994PM07000011 
1,4-Dioxane (DX) is a rodent carcinogen which induces liver tumours in both sexes of rats and mice and nasal tumours in rats. Mirkova has reported that DX is weakly active in the mouse bone marrow micronucleus assay. Studies were therefore conducted in an attempt to reproduce independently this weak activity. The present studies were performed during our transition from the use of Giemsa to acridine orange (AO) as our stain of choice for bone marrow smears. Thus, one study was analysed using Giemsa stained smears and the rest using AO stained smears. 
1,4-dioxane; bone marrow; micronucleus assay 
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