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Citation
Tags
HERO ID
196140
Reference Type
Journal Article
Subtype
Letter
Title
Comments on R. Karbe and R.L. Kerlin (2002) Cystic degeneration/spongiosis hepatis (Toxicol Pathol 30 (2), 216-227)
Author(s)
Bannasch, P
Year
2003
Is Peer Reviewed?
1
Journal
Toxicologic Pathology
ISSN:
0192-6233
EISSN:
1533-1601
Volume
31
Issue
5
Page Numbers
566-570
Language
English
PMID
14692626
DOI
10.1080/01926230390224700
Web of Science Id
WOS:000184789300013
Abstract
Karbe and Kerlin have questioned the classification of spongiosis hepatis as a preneoplastic lesion or even a benign neoplasm, designated as spongiotic pericytoma, and have proposed to use the term cystic degeneration for this lesion in rats and fish. However, the reclassification of spongiosis as cystic degeneration is unwarranted for several reasons. In the rat, spongiosis hepatis represents a specific pathomorphologic entity, originating from the perisinusoidal (Ito) cells; it may occur spontaneously in aged animals but its number and size increases significantly after exposure to various (hepato)carcinogens. Comparative morphological, immunohistochemical, and autoradiographic studies in rats exposed to N-nitrosomorpholine revealed that spongiosis hepatis is an integral part of larger proliferative Ito-cell aggregates showing an autonomous, progressive growth. The classification of spongiosis hepatis as a benign neoplasm is based on these findings that endorse and extend previous considerations on the preneoplastic or neoplastic nature of this lesion. Irrespective of the classification of spongiosis hepatis as a benign neoplastic or a preneoplastic lesion, there is compelling evidence for its reliability as a sensitive marker for (hepato)carcinogenic effects in rats and fish. The data collected by Karbe and Kerlin support rather than contradict the reliability of spongiosis hepatis as an effect marker for carcinogens.
Keywords
Spongiosis hepatis; spongiotic pericytoma; perisinusoidal (Ito) cell neoplasm; perisinusoidal cell sarcoma; effect marker for (hepato) carcinogens
Tags
IRIS
•
1,4-Dioxane - with inhalation update
Final (2013)
External Review Draft (2011)
OPPT REs
•
OPPT_1,4-Dioxane_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
MOA
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