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2044329 
Journal Article 
Xestosaprols from the Indonesian Marine Sponge Xestospongia sp 
Dai, J; Sorribas, A; Yoshida, WY; Kelly, M; Williams, PG 
2010 
Yes 
Journal of Natural Products
ISSN: 0163-3864
EISSN: 1520-6025 
73 
6 
1188-1191 
English 
20503979 
WOS:000279070300033 
Eight pentacyclic compounds, xestosaprols F-M (1-8), were isolated from a marine sponge belonging to the genus Xestospongia. The structures of these new compounds were determined on the basis of extensive analyses of NMR experiments and mass spectrometric measurements. These compounds inhibited the aspartic protease BACE1 at moderate levels in a dose-dependent manner. 
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