US EPA

2055926 

Journal Article 

Excitotoxicity: A possible central mechanism in fluoride neurotoxicity 

Blaylock, RL 

2004 

Yes 

Fluoride
ISSN: 0015-4725 

37 

4 

301-314 

WOS:000226445600010 

http://://BCI:BCI200500129186
Exit
 

Recent evidence indicates that fluoride produces neuronal destruction and synaptic injury by a mechanism that involves free radical production and lipid peroxidation. For a number of pathological disorders of the central nervous system (CNS), excitotoxicity plays a critical role. Various studies have shown that many of the neurotoxic metals, such as mercury, lead, aluminum, and iron also injure neural elements in the CNS by an excitotoxic mechanism. Free radical generation and lipid peroxidation, especially in the face of hypomagnesemia and low neuronal energy production, also magnify excitotoxic sensitivity of neurons and their elements. This paper reviews briefly some of the studies that point to a common mechanism for the CNS neurotoxic effects of fluoride and calls for research directed toward further elucidation of this mechanism. 

aspartate; excitotoxicity; fluoride neurotoxicity; fluoroaluminum complexes; glutamate; 4-hydroxynonenal; melatonin; neurodegeneration; peroxynitritel; reactive nitrogen species; reactive oxygen species