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2089587 
Journal Article 
Review 
Gene by Environment Interaction in Asthma 
London, SJ; Romieu, I 
2009 
Yes 
Annual Review of Public Health
ISSN: 0163-7525
EISSN: 1545-2093 
Annual Review of Public Health 
30 
55-80 
English 
18980546 
WOS:000268071900005 
Marked international differences in rates of asthma and allergies and the importance of family history highlight the primacy of interactions between genetic variation and the environment in asthma etiology. Environmental tobacco smoke (or secondhand smoke), ambient air pollutants, and endotoxin and/or other pathogen-associated molecular patterns are the ambient exposures studied most frequently for interactions with genetic polymorphisms in asthma. To date, results from the literature remain inconclusive. Most published studies are underpowered to study interactions between genetic polymorphisms and ambient exposures, each with weak effects. Strategies to increase power include cooperation across studies to increase sample sizes and improve measures of both exposure and asthma phenotypes. Genome-wide association studies hold promise for identifying unexpected gene environment interactions, but given the statistical power issues, candidate gene association studies will remain important. New tools are enabling the study of epigenetic mechanisms for environmental interactions. 
genetic polymorphism endotoxin; air pollution; tobacco smoke pollution; environmental pollutants 
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