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2090818 
Journal Article 
Review 
Cystic fibrosis: A review of epidemiology and pathobiology 
Strausbaugh, SD; Davis, PB 
2007 
Yes 
Clinics in Chest Medicine
ISSN: 0272-5231 
28 
2 
279-+ 
English 
17467547 
WOS:000246780300003 
Improvements in outcomes for patients who have cystic fibrosis (CF) have been striking in the last 30 years. Median survival now approaches the fifth decade of life. Advances in the understanding of the basic defect and the pathobiology of CF have led to new treatments, some of which have undoubtedly contributed to this success. Improved understanding of the basic defect and the acquisition and maintenance of epidemiologic resources for the CF population in the United States have allowed us to determine predictors of survival and identify genetic, environmental, and therapeutic factors that may influence it. This article reviews some of the key epidemiologic and pathobiologic factors discovered thus far. 
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