US EPA

2222925 

Technical Report 

Effects of Oral Guanidinium 3,4-dinitropyrazolate (GDNP) Exposure to Female Rats (Rattus norvegicus) 

Williams, L; Adams, V; Mccain, W; Eck, W; Crouse, L 

2012 

NTIS/11560003 

GRA and I 

GRA and I 

The Army Environmental Quality Technology Program (EQT) Ordnance Environmental Program (OEP) is dedicated to finding replacements for RDX that will reduce or eliminate the health risks from environmental exposure and will reduce adverse ESOH effects and effects of RDX on readiness and costs associated with training. USARDECOM-sponsored work with Physical Sciences Inc. (Andover, MA) and BAE Ordnance Systems (Kingsport, TN) developed GDNP as a possible replacement for RDX. This document reports the conduct, findings, and conclusions of a progressive series of two oral toxicity studies performed with GDNP in laboratory female rats. The LD50 in female rats in tap water solution if 720 mg/kg. Daily oral exposure to 500 mg/kg-d of GDNP for 14-days causes weight loss, increased liver and spleen organ weights, and adverse histopathologic events in kidney and spleen. These adverse events were not observed in animals receiving lower doses of GDNP is low and is not limiting to the continued development of GDNP.