Exhaled nitric oxide in acute RSV bronchiolitis
Sivan, Y; Gadish, T; Fireman, E; Merimovitch, T; Soferman, R
HERO ID
2267824
Reference Type
Journal Article
Subtype
Abstract
Year
2010
Language
English
| HERO ID | 2267824 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2010 |
| Title | Exhaled nitric oxide in acute RSV bronchiolitis |
| Authors | Sivan, Y; Gadish, T; Fireman, E; Merimovitch, T; Soferman, R |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 181 |
| Page Numbers | A3310 |
| Abstract | Background: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants. Severe RSV bronchiolitis contributes substantially to the risk of recurrent wheezing and asthma in childhood. Fractional exhaled nitric oxide (FeNO) is a marker of eosinophilic airway inflammation and has been shown to be high in asthmatics compared to controls. We measured FeNO in infants with acute RSV bronchiolitis in comparison to non-RSV recurrent wheezy babies and healthy controls. Methods: FeNO was compared between infants with laboratory confirmed acute RSV bronchiolitis and two control groups: healthy infants and infants with recurrent wheezing. FeNO levels were followed in two visits over four months after the acute RSV bronchiolitis. Results: The study included 44 infants with acute RSV bronchiolitis (mean age 6.83+7.33 months), 21 infants with recurrent wheezing (10.85+7.59 months) and 32 healthy age-matched controls (6.88+9.07 months). Mean FeNO levels were: 1.8+1.7 ppb, 4.86+7.49 ppb and 6.29+3.3 ppb, respectively (P < 0.001 for RSV positive infants vs. healthy controls). FeNO levels at the 2 and 4-months follow-up visits increased to 7.8+5.7 ppb and 11.3+6.3 ppb, respectively (P = 0.001) (Fig 1). Conclusions: FeNO levels are temporarily reduced during acute RSV bronchiolitis and increase during convalescence to normal levels and above. The mechanisms for this suppression and its relation for future wheezing and asthma should be further investigated. Figure 1: FeNO levels in the RSV bronchiolitis group over time *figure in pdf |
| Doi | 10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A3310 |
| Wosid | WOS:000208771002421 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | New Orleans, LA |
| Conference Name | American Thoracic Society 2010 International Conference |
| Conference Date | May 14-19, 2010 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
|