US EPA

2306682 

Journal Article 

Genotoxicity of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ (TM)) 

Nakano, M; Suzuki, H; Imarnura, T; Lau, A; Lynch, B 

2013 

1 

Regulatory Toxicology and Pharmacology
ISSN: 0273-2300
EISSN: 1096-0295 

ACADEMIC PRESS INC ELSEVIER SCIENCE 

SAN DIEGO 

67 

2 

189-197 

English 

23891671 

10.1016/j.yrtph.2013.07.007 

WOS:000326559000007 

The genotoxic potential of pyrroloquinoline quinone (PQQ) disodium salt (BioPQQ™) was evaluated in a battery of genotoxicity tests. The results of the bacterial mutation assay (Ames test) were negative. Weak positive results were obtained in 2 separate in vitro chromosomal aberration test in Chinese hamster lung (CHL) fibroblasts. Upon testing in an in vitro chromosomal aberration test in human peripheral blood lymphocytes, no genotoxic activity of PQQ was noted. In the in vivo micronucleus assay in mice, PQQ at doses up to 2,000 mg/kg body weight demonstrated that no genotoxic effects are expressed in vivo in bone marrow erythrocytes. The weak responses in the in vitro test CHL cells were considered of little relevance under conditions of likely human exposure. PQQ disodium was concluded to have no genotoxic activity in vivo. 

Pyrroloquinoline quinone; Genotoxicity; Ames test; Chromosome aberration test; Micronucleus test