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HERO ID
2444381
Reference Type
Journal Article
Subtype
Review
Title
Toxicological and epidemiological studies of cardiovascular effects of ambient air fine particulate matter (PM2.5) and its chemical components: Coherence and public health implications
Author(s)
Lippmann, M
Year
2014
Is Peer Reviewed?
Yes
Journal
Critical Reviews in Toxicology
ISSN:
1040-8444
EISSN:
1547-6898
Volume
44
Issue
4
Page Numbers
299-347
Language
English
PMID
24494826
DOI
10.3109/10408444.2013.861796
Web of Science Id
WOS:000335217300001
URL
http://www.ncbi.nlm.nih.gov/pubmed/24494826
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Abstract
Recent investigations on PM2.5 constituents' effects in community residents have substantially enhanced our knowledge on the impacts of specific components, especially the HEI-sponsored National Particle Toxicity Component (NPACT) studies at NYU and UW-LRRI that addressed the impact of long-term PM2.5 exposure on cardiovascular disease (CVD) effects. NYU's mouse inhalation studies at five sites showed substantial variations in aortic plaque progression by geographic region that was coherent with the regional variation in annual IHD mortality in the ACS-II cohort, with both the human and mouse responses being primarily attributable to the coal combustion source category. The UW regressions of associations of CVD events and mortality in the WHI cohort, and of CIMT and CAC progression in the MESA cohort, indicated that SO4- had stronger associations with CVD-related human responses than OC, EC, or Si. The LRRI's mice had CVD-related biomarker responses to SO4=. NYU also identified components most closely associated with daily hospital admissions (OC, EC, Cu from traffic and Ni and V from residual oil). For daily mortality, they were from coal combustion (SO4-, Se, and As). While the recent NPACT research on PM2.5 components that affect CVD has clearly filled some major knowledge gaps, and helped to define remaining uncertainties, much more knowledge is needed on the effects in other organ systems if we are to identify and characterize the most effective and efficient means for reducing the still considerable adverse health impacts of ambient air PM. More comprehensive speciation data are needed for better definition of human responses.
Keywords
Annual mortality; aortic plaque; cardiac function; cardiovascular effects; daily mortality; hospital admissions; ischemic heart disease; particle speciation PM2.5
Tags
•
ISA-PM (2019)
•
LitSearch-NOx (2024)
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