Cardiovascular effects of concentrated ambient fine and ultrafine particulate matter exposure in healthy older volunteers | Health & Environmental Research Online (HERO)

HERO ID

2625529

Reference Type

Journal Article

Title

Cardiovascular effects of concentrated ambient fine and ultrafine particulate matter exposure in healthy older volunteers

Author(s)

Tong, H; Bassett, M; Montilla, T; Caughey, M; Hinderliter, A; Rappold, AG; Diaz-Sanchez, D; Devlin, RB; Samet, JM

Year

2010

Is Peer Reviewed?

Yes

Journal

American Journal of Respiratory and Critical Care Medicine
ISSN: 1073-449X
EISSN: 1535-4970

Volume

181

Page Numbers

A2426

Language

English

DOI

10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A2426

Web of Science Id

WOS:000208771001340

URL

http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2010.181.1_MeetingAbstracts.A2426
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Relationship(s)

is part of a larger document 3452678 Proceedings of the American Thoracic Society 2010 International Conference, May 14-19, 2010, New Orleans

Abstract

Rationale: Epidemiological studies have shown an association between the incidence of adverse cardiovascular effects and exposure to ambient particulate matter (PM). Advanced age is among the factors identified as conferring susceptibility to PM inhalation. In order to characterize the cardiopulmonary effects of PM in older healthy subjects, we studied a cohort of 11 subjects undergoing face-mask exposure to filtered air (FA) or fine and ultrafine PM (CAP) concentrated in real time from the ambient air in Chapel Hill, NC.

Methods: Baseline brachial artery indices and endothelium-dependent flow-mediated dilation (FMD) were assessed by ultrasound imaging pre, immediately post and 18 hr post exposure. Blood pressure was monitored every 15 min during exposure, every 30 min during waking time, and every 2 hr during sleep hrs. Heart rate variability (HRV) was also measured pre, immediately post and 18 hr post exposure. Pulmonary function and coagulation markers were also evaluated.

Results: Preliminary findings indicate that exposure to CAP resulted in a statistically significant reduction of baseline brachial artery blood flow compared to pre-exposure measured as velocity time integral (-0.09±1.99 cm in FA vs. -3.64±1.92 cm in CAP; p<0.05) without an effect on FMD. Diastolic blood pressure was increased significantly for the first one and half hrs after CAP exposure (77±3 mmHg in FA vs. 80±3 mmHg in CAP; p<0.05). HRV after CAP exposure was decreased compared to FA values. In addition, very low density lipoprotein concentrations were increased immediately after CAP exposure while total cholesterol, erythrocyte, and platelets were decreased 18 hr post CAP exposure.

Conclusions: These findings show that short-term exposure to CAP results in acute cardiovascular effects in healthy older adults. This abstract of a proposed presentation does not necessarily reflect EPA policy.

Conference Name

American Thoracic Society 2010 International Conference

Conference Location

New Orleans, LA

Conference Dates

May 14-19, 2010