Health & Environmental Research Online (HERO)


Print Feedback Export to File
2653063 
Journal Article 
Characteristics of trace metals in fine (PM2.5) and inhalable (PM10) particles and its health risk assessment along with in-silico approach in indoor environment of India 
Satsangi, PG; Yadav, S; Pipal, AS; Kumbhar, N 
2014 
1 
Atmospheric Environment
ISSN: 1352-2310
EISSN: 1873-2844 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
92 
384-393 
WOS:000338810800040 
Indoor concentrations of fine (PM2.5: aerodynamic diameter <= 2.5) and inhalable (PM10: aerodynamic diameter <= 10 mu m) particles and its associated toxic metals are of concern now-a-days due to its effects on human health and environment. PM10 and PM2.5 samples were collected from indoor microenvironments on glass fiber and l'IFE filter paper using low volume air sampler in Pune. The average concentration of PM2.5 and PM10 were 89.7 +/- 43.2 mu g m(-3) and 138.2 +/- 68.2 mu g m(-3) at urban site while it was 197.5 +/- 84.3 and 287 +/- 92 mu g m(-3) at rural site. Trace metals such as Cd, Co, Cr, Cu, Fe, Mn, Pb, Sb and Zn in particulate matter were estimated by ICP-AES. Concentrations of crustal metals were found to be higher than the carcinogenic metals in both the microenvironments. On the contrary the soluble and bioavailability fraction of carcinogenic metals were found higher thus it may cause the higher risk to human health. Therefore, cancer risk assessment of carcinogenic metals; Cr, Ni and Cd was calculated. Among the carcinogenic metals, Ni showed highest cancer risk in indoor PM. The higher cancer risk assessment of Ni has been supported by In-silico study which suggested that Ni actively formed coordination complex with histone proteins (i.e. H3-Ni/H4-Ni) by maintaining strong hydrogen bonding interactions with Asp and Glu residues of nucleosomal proteins. Present In-silico study of Ni-histone complexes will help to emphasize the possible role of Asp and Glu residues in DNA methylation, deacetylation and ubiquitinations of nucleosomal proteins. Hence, this study could pave the way to understand the structural consequence of Ni in nucleosomal proteins and its impact on epigenetic changes which ultimately cause lung and nasal cancer. (C) 2014 Elsevier Ltd. All rights reserved. 
IAQ; PM concentration; Trace metals; Metal toxicity; Health risk assessment; In-silico study 
• ISA-PM (2019)