US EPA

2843332 

Journal Article 

Molecular mechanisms governing Arabidopsis iron uptake 

Brumbarova, T; Bauer, P; Ivanov, R 

2015 

1 

Trends in Plant Science
ISSN: 1360-1385 

20 

2 

124-133 

25499025 

10.1016/j.tplants.2014.11.004 

WOS:000349504900010 

Plants are the principal source of dietary iron (Fe) for most of Earth's population and Fe deficiency can lead to major health problems. Developing strategies to improve plant Fe content is a challenge because Fe is essential and toxic and therefore regulating Fe uptake is crucial for plant survival. Acquiring soil Fe relies on complex regulatory events that occur in root epidermal cells. We review recent advances in elucidating many aspects of the regulation of Fe acquisition. These include the expanding protein network involved in FER-LIKE IRON DEFICIENCY INDUCED TRANSCRIPTION FACTOR (FIT)-dependent gene regulation and novel findings on the intracellular trafficking of the Fe transporter IRON-REGULATED TRANSPORTER 1 (IRT1). We outline future challenges and propose strategies, such as exploiting natural variation, to further expand our knowledge. 

iron uptake; transcriptional regulation; phytohormones; IRT1 trafficking