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HERO ID
2849901
Reference Type
Journal Article
Title
Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation
Author(s)
Liotta, F; Querci, V; Mannelli, G; Santarlasci, V; Maggi, L; Capone, M; Rossi, MC; Mazzoni, A; Cosmi, L; Romagnani, S; Maggi, E; Gallo, O; Annunziato, F
Year
2015
Is Peer Reviewed?
Yes
Journal
British Journal of Cancer
ISSN:
0007-0920
EISSN:
1532-1827
Volume
112
Issue
4
Page Numbers
745-754
Language
English
PMID
25647013
DOI
10.1038/bjc.2015.15
Web of Science Id
WOS:000349902600018
Abstract
Background: Cancer is a multifactorial disease not only restricted to transformed epithelium, but also involving cells of the immune system and cells of mesenchymal origin, particularly mesenchymal stem cells (MSCs). Mesenchymal stem cells contribute to blood- and lymph- neoangiogenesis, generate myofibroblasts, with pro-invasive activity and may suppress anti-tumour immunity.
Methods: In this paper, we evaluated the presence and features of MSCs isolated from human head neck squamous cell carcinoma (HNSCC).
Results: Fresh specimens of HNSCC showed higher proportions of CD90+ cells compared with normal tissue; these cells co-expressed CD29, CD105, and CD73, but not CD31, CD45, CD133, and human epithelial antigen similarly to bone marrow-derived MSCs (BM-MSCs). Adherent stromal cells isolated from tumour shared also differentiation potential with BM-MSCs, thus we named them as tumour-MSCs. Interestingly, tumour-MSCs showed a clear immunosuppressive activity on in vitro stimulated T lymphocytes, mainly mediated by indoelamine 2,3 dioxygenase activity, like BM-MSCs. To evaluate their possible role in tumour growth in vivo, we correlated tumour-MSC proportions with neoplasm size. Tumour-MSCs frequency directly correlated with tumour volume and inversely with the frequency of tumour-infiltrating leukocytes.
Conclusions: These data support the concept that tumour-MSCs may favour tumour growth not only through their effect on stromal development, but also by inhibiting the anti-tumour immune response.
Tag
IRIS
•
Chromium VI
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