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HERO ID
2898472
Reference Type
Journal Article
Title
Mesoporous calcium-silicon xerogels with mesopore size and pore volume influence hMSC behaviors by load and sustained release of rhBMP-2
Author(s)
Song, W; Li, X; Qian, Jun; Lv, G; Yan, Y; Su, J; Wei, Jie
Year
2015
Is Peer Reviewed?
Yes
Journal
International Journal of Nanomedicine
ISSN:
1176-9114
EISSN:
1178-2013
Volume
10
Page Numbers
1715-1726
Language
English
PMID
25784801
DOI
10.2147/IJN.S70934
Web of Science Id
WOS:000350605900001
Abstract
Mesoporous calcium-silicon xerogels with a pore size of 15 nm (MCS-15) and pore volume of 1.43 cm(3)/g were synthesized by using 1,3,5-mesitylene (TMB) as the pore-expanding agent. The MCS-15 exhibited good degradability with the weight loss of 50 wt% after soaking in Tris-HCl solution for 56 days, which was higher than the 30 wt% loss shown by mesoporous calcium-silicon xerogels with a pore size of 4 nm (MCS-4). The pore size and pore volume of MCS-15 had significant influences on load and release of recombinant human bone morphogenetic protein-2 (rhBMP-2). The MCS-15 had a higher capacity to encapsulate a large amount of rhBMP-2; it could adsorb 45 mg/g of rhBMP-2 in phosphate-buffered saline after 24 hours, which was more than twice that with MCS-4 (20 mg/g). Moreover, the MCS-15 system exhibited sustained release of rhBMP-2 as compared with MCS-4 system (showing a burst release). The MCS-15/rhBMP-2 system could promote the proliferation and differentiation of human mesenchymal stem cells, showing good cytocompatibility and bioactivity. The results indicated that MCS-15, with larger mesopore size and higher pore volume, might be a promising carrier for loading and sustained release of rhBMP-2, which could be used as bone repair material with built-in osteoinduction function in bone reconstruction.
Keywords
mesoporous calcium-silicon xerogels; pore size; pore volume; load-release; rhBMP-2
Tags
IRIS
•
Trimethylbenzenes (Interagency Science Discussion Draft)
Literature Search Update
Literature Search Update- Excluded
Excluded by Title/Abstract
Non-relevant Biological System or Chemical
•
Trimethylbenzenes (TMB)
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