US EPA

3041958 

Book/Book Chapter 

Dipropylene glycol 

GDCh Advisory Committee on Existing Chemicals :: BUA 

1996 

S. Hirzel 

Stuttgart, Germany 

English 

is related to other part(s) 1744618 (addendum)

Degradability. DiPG is not readily biodegradable in laboratory tests. A more rapid primary degradation of over 90 % could be attained with adapted microorganisms, but under optimized laboratory conditions. In separate tests (likewise under optimal laboratory conditions), the subsequent product propylene glycol is readily biodegraded aerobically as well as anaerobically. A hydrolytic or photochemical degradation is unexpected under environmental conditions. A degradation with a half-life of app. 13 hours occurs in the atmosphere by reaction with photochemically formed OH-radicals. Accumulation. The danger of bioaccumulation is considered to be low. In one experimental study, BCF values ranging from 0.3 to 4.6 were found. Because geoaccumulation is not expected on the basis of calculated physicochemical parameters and the substance is considered to be not readily biodegradable, DiPG transport via leachate to the groundwater is expected. Ecotoxicoloeical Effects. For bacteria, there is a 13,5 % inhibition of cell reproduction at a DiPG concentration of 1,000 mg/l. No data are available for plants and invertebrates. The acute toxicity for fish (Carassius auratus) and for tadpoles of Rana brevipoda porosa lies at and gt; 5,000 mg/l and is 3,181 mg/l for the larvae of the frog Xenopus laevis. Toxicoiolgical Aspect. DiPG is rapidly absorbed after oral and i.v. application. DiPG is no longer detectable in blood after 24 hours. No data are available on the mode of action of the substance. The oral LD50 value is 1.5-15 g/kg b.w. for the rat and 17.6 g/kg b.w. for the guinea pig. After intraperitoneal application, the LD50 value for the rat is 10-10.6 g/kg b.w. and for the mouse, 4.5-4.6 g/kg b.w. After intravenous application, LD50 values of 11.5 and 5-8 g/kg b.w. are found for the dog and rabbit, respectively. Dermal applications to the rabbit produced LD50 values of and gt; 5 g/kg b.w. and and gt; 20 g/kg b.w. DiPG acts slightly irritating to the eye and skin. No data are available on the sensitizing effect. Within the framework of older studies on the repeated application of DiPG, individual cases of death occurred at very high dosages as well as degenerations of the tubulus epithelia in the kidney and single cases of degeneration of the parenchyma of the liver. A numerical NOEL cannot be derived according to current criteria; it ought to lie, however, in the gram-range corresponding to the low toxicity. An Ames-test and one mouse-lymphoma test were negative. No data are available on carcinogenicity. There were no indications found of a teratogenic or embryotoxic effect in one teratogenicity study on rats. The NOAEL maternal is 800 mg/kg b.w. and the NOAELfetal 5,000 mg/kg b.w. No data are available on the effects on the immune system. For humans, DiPG showed no photosensitizing properties and no or only low sensitizing effects after repeated dermal application. 

GDCh-BUA 

BUA Report 162 

9783777607245