US EPA

31402 

Journal Article 

Ethanol and methanol metabolites in alcohol withdrawal 

Magrinat, G; Dolan, JP; Biddy, RL; Miller, LD; Korol, B 

1973 

1 

Nature
ISSN: 0028-0836
EISSN: 1476-4687 

IPA/74/107136 

244 

London 

234-235 

English 

4583098 

10.1038/244234a0 

WOS:A1973Q253600038 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015835749&doi=10.1038%2f244234a0&partnerID=40&md5=1055867089e75beb113c46ed93af0c58
Exit
 

IPA COPYRIGHT: ASHP Twenty-one human alcoholic subjects were studied for blood concentrations of ethanol, methanol, acetaldehyde, and formaldehyde formate during withdrawal. The subjects were separated into high (|GT/100mg./100ml.) and low ((100mg./100ml.))blood alcohol groups. In all cases the high-alcohol group had statistically significant increases in blood concentrations of ethanol, methanol and their metabolites, and also showed total disrupted withdrawal signs and symptoms significantly greater than those of the low-alcohol group. The delayed and marked increase in blood concentrations of the methanol metabolites, formaldehyde-formate, supports the hypothesis that the oxidative enzyme systems induced by chronic alcohol consumption will shift to metabolizing methanol when ethanol is abruptly withdrawn. A critical accumulation of these methanol metabolites may be the primary factor which results in the expression of withdrawal. The much higher blood acetaldehyde and formaldehyde formate levels reported for street alcoholics used in this study compared with levels obtained from alcoholics in a controlled laboratory indicate that caution must be exercised in the interpretation, extrapolation, or application of the results obtained in the artificial setting to what is happening in the real world. 

Alcoholism; withdrawal; blood levels; Toxicity; alcohols; withdrawal; Alcohols; blood levels; metabolites; during withdrawal; Metabolism; blood levels; HUMAN