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Citation
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HERO ID
3270449
Reference Type
Journal Article
Title
The preferential accumulation of heavy metals in different tissues following frequent respiratory exposure to PM2.5 in rats
Author(s)
Li, Q; Liu, H; Alattar, M; Jiang, S; Han, J; Ma, Y; Jiang, C
Year
2015
Is Peer Reviewed?
1
Journal
Scientific Reports
EISSN:
2045-2322
Publisher
NATURE PUBLISHING GROUP
Location
LONDON
Volume
5
Page Numbers
16936
Language
English
PMID
26582271
DOI
10.1038/srep16936
Web of Science Id
WOS:000364946900001
Abstract
This study aimed to explore the pattern of accumulation of some of main heavy metals in blood and various organs of rats after exposed to the atmospheric fine particulate matter (PM2.5). Rats were randomly divided into control and three treatment groups (tracheal perfusion with 10 mg/kg, 20 mg/kg and 40 mg/kg of PM2.5 suspension liquid, respectively). Whole blood and the lung, liver, kidney, and cerebral cortex were harvested after rats were treated and sacrificed. The used heavy metals were detected using inductively coupled plasma-mass spectrometry (ICP-MS) instrument. As results, Lead was increased in the liver, lung and cerebral cortex and the level of manganese was significantly elevated in the liver and cerebral cortex in PM2.5 treated rats. Besides, arsenic was prominently enriched both in cerebral cortex and in blood, and so did the aluminum in the cerebral cortex and the copper in the liver. However, cadmium, chromium and nickel have shown no difference between the control group and the three PM2.5 treated groups. Following the exposure of PM2.5, different heavy metals are preferentially accumulated in different body tissues.
Tags
IRIS
•
Arsenic Hazard ID
Lit Search Updates Oct 2015 to Jan 2019
PubMed
WOS
2.5 Update 2015-2019: Title & Abstract Screening
Not relevant to PECO
NAAQS
•
ISA-PM (2019)
Considered
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