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3272439 
Book/Book Chapter 
Reproductive toxicity of polycyclic aromatic hydrocarbons: Occupational relevance 
Ramesh, A; Archibong, AE 
2011 
Academic Press 
San Diego, CA 
Reproductive and developmental toxicology 
577-591 
English 
WOS:000318575300044 
has other version or edition 4241016 Reproductive toxicity of polycyclic aromatic hydrocarbons
This chapter describes how globally human health is adversely influenced by exposure to toxic chemicals that act as endocrine disruptors. Polycyclic aromatic hydrocarbons (PAHs) constitute a large generic group of organic compounds with two or more fused aromatic rings. Exposure to this contributes to the declining fertility in men and women, which is discussed in detail here. Exclusive sources for B(a)P contamination of the environment and exposure to humans include industrial and automobile emissions, hazardous waste sites, cigarette smoke, biomass burning, municipal incinerators, volcanic eruptions, home heating and consumption of charcoal broiled and smoked foods. Vulnerable organs such as the gonads are exposed directly to inhaled B(a)P. Endocrine-disrupting chemicals may have very specific effects on the cells within the ovary and because of the intense interdependency of cells in this organ, cause a disruption in normal folliculogenesis, ovulatory process, fertilization and subsequent embryo development. The nervous system, liver, gastrointestinal and genitourinary tracts and cardiovascular system are all targets for PAHs' adverse effects. Transplacental exposures of fetuses to PAHs affect fetal development and pregnancy outcomes in both laboratory animals and humans. The sexual maturation and growth of the female organs are under estrogen regulation and B(a)P-induced reduction of estrogen secretion at puberty leads to delay in these processes. Furthermore, in addition to the growth effects estrogen has on the uterine and oviductal musculature, it plays a major role in the development of the endometrial lining. Polyaromatic hydrocarbons have been known to cause DNA damage both in laboratory animals and humans. 
Gupta, RC 
9780123820327