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HERO ID
4241016
Reference Type
Book/Book Chapter
Title
Reproductive toxicity of polycyclic aromatic hydrocarbons
Author(s)
Ramesh, A; Harris, KJ; Archibong, AE
Year
2017
Publisher
Academic Press
Location
San Diego, CA
Book Title
Reproductive and developmental toxicology
Page Numbers
745-763
Language
English
DOI
10.1016/B978-0-12-804239-7.00040-8
Relationship(s)
has other version or edition
3272439
: Occupational relevance
is a chapter of
4779372
Reproductive and developmental toxicology (Second edition)
Abstract
Infertility cases among men and women of reproductive age have registered a global increase in the last decade. Some infertility cases are idiopathic in nature and may originate from exposures to chemical contaminants in domestic and occupational environmental settings. One group of chemical contaminants that have generated a lot of interest in view of their ubiquitous environmental distribution is polycyclic aromatic hydrocarbons (PAHs), a family of semivolatile and lipophilic compounds that are products of combustion. This chapter focuses on how PAHs impact reproduction and development in animal models and humans using benzo(a)pyrene [B(a)P] as a prototypical PAH toxicant. Topics covered in this chapter include the effect of B(a)P on female reproduction, follicular growth, fetal survival, puberty, reproductive tract function and menopause, male reproduction, and PAH-induced DNA damage in reproductive tissues. The mechanisms that underlie these toxic effects are explained in the context of B(a)P biotransformation and kinetics of B(a)P-reactive metabolite disposition in reproductive tissues. The information presented in this chapter is expected to provoke debate among toxicologists and also raise awareness among caregivers about damage to reproductive health when occupationally exposed individuals dominate the patient populations that frequent infertility clinics.
Keywords
Developmental toxicity; PAH; Polycyclic aromatic hydrocarbons; Reproductive toxicity
Edition
2nd
Editor(s)
Gupta, RC
ISBN
9780128042397
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