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4241016 
Book/Book Chapter 
Reproductive toxicity of polycyclic aromatic hydrocarbons 
Ramesh, A; Harris, KJ; Archibong, AE 
2017 
Academic Press 
San Diego, CA 
Reproductive and developmental toxicology 
745-763 
English 
has other version or edition 3272439 : Occupational relevance
is a chapter of 4779372 Reproductive and developmental toxicology (Second edition)
Infertility cases among men and women of reproductive age have registered a global increase in the last decade. Some infertility cases are idiopathic in nature and may originate from exposures to chemical contaminants in domestic and occupational environmental settings. One group of chemical contaminants that have generated a lot of interest in view of their ubiquitous environmental distribution is polycyclic aromatic hydrocarbons (PAHs), a family of semivolatile and lipophilic compounds that are products of combustion. This chapter focuses on how PAHs impact reproduction and development in animal models and humans using benzo(a)pyrene [B(a)P] as a prototypical PAH toxicant. Topics covered in this chapter include the effect of B(a)P on female reproduction, follicular growth, fetal survival, puberty, reproductive tract function and menopause, male reproduction, and PAH-induced DNA damage in reproductive tissues. The mechanisms that underlie these toxic effects are explained in the context of B(a)P biotransformation and kinetics of B(a)P-reactive metabolite disposition in reproductive tissues. The information presented in this chapter is expected to provoke debate among toxicologists and also raise awareness among caregivers about damage to reproductive health when occupationally exposed individuals dominate the patient populations that frequent infertility clinics. 
Developmental toxicity; PAH; Polycyclic aromatic hydrocarbons; Reproductive toxicity 
2nd 
Gupta, RC 
9780128042397