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Citation
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HERO ID
3309236
Reference Type
Journal Article
Title
Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema
Author(s)
You, Ran; Lu, Wen; Shan, M; Berlin, JM; Samuel, ELG; Marcano, DC; Sun, Z; Sikkema, WKA; Yuan, X; Song, L; Hendrix, AY; Tour, JM; Corry, DB; Kheradmand, F
Year
2015
Is Peer Reviewed?
Yes
Journal
eLife
ISSN:
2050-084X
Volume
4
DOI
10.7554/eLife.09623
Web of Science Id
WOS:000363798000001
Abstract
Chronic inhalation of cigarette smoke is the major cause of sterile inflammation and pulmonary emphysema. The effect of carbon black (CB), a universal constituent of smoke derived from the incomplete combustion of organic material, in smokers and non-smokers is less known. In this study, we show that insoluble nanoparticulate carbon black (nCB) accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c(+) lung antigen presenting cells (APC) of mice exposed to smoke. Likewise, nCB intranasal administration induced emphysema in mouse lungs. Delivered by smoking or intranasally, nCB persisted indefinitely in mouse lung, activated lung APCs, and promoted T helper 17 cell differentiation through double-stranded DNA break (DSB) and ASC-mediated inflammasome assembly in phagocytes. Increasing the polarity or size of CB mitigated many adverse effects. Thus, nCB causes sterile inflammation, DSB, and emphysema and explains adverse health outcomes seen in smokers while implicating the dangers of nCB exposure in non-smokers.
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ISA-PM (2019)
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