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Citation
Tags
HERO ID
3350464
Reference Type
Journal Article
Title
Gestational and early postnatal exposure to an environmentally relevant mixture of brominated flame retardants: General toxicity and skeletal variations
Author(s)
Tung, EWY; Yan, H; Lefèvre, PLC; Berger, RG; Rawn, DFK; Gaertner, DW; Kawata, A; Rigden, M; Robaire, B; Hales, BF; Wade, MG
Year
2016
Is Peer Reviewed?
Yes
Journal
Birth Defects Research, Part B: Developmental and Reproductive Toxicology
ISSN:
1542-9733
EISSN:
1542-9741
Volume
107
Issue
3
Page Numbers
157-168
Language
English
PMID
27286044
DOI
10.1002/bdrb.21180
Web of Science Id
WOS:000379548700004
Abstract
Brominated flame retardants (BFRs) are stable environmental contaminants known to exert endocrine-disrupting effects. Developmental exposure to polybrominated diphenyl ethers (PBDEs) is correlated with impaired thyroid hormone signaling, as well as estrogenic and anti-androgenic effects. As previous studies have focused on a single congener or technical mixture, the purpose of the current study was to examine the effects of gestational and early postnatal exposure to an environmentally relevant mixture of BFRs designed to reflect house dust levels of PBDEs and hexabromocyclododecane on postnatal developmental outcomes. Pregnant Sprague-Dawley rats were exposed to the PBDE mixture from preconception to weaning (PND 21) through the diet containing 0, 0.75, 250, and 750 mg mixture/kg diet. BFR exposure induced transient reductions in body weight at PND 35 in male and from PND 30-45 in female offspring (250 and 750 mg/kg). Liver weights (PND 21) and xenobiotic metabolizing enzyme activities (PND 21 and 46) were increased in both male and female offspring exposed to 250 and 750 mg/kg diets. Furthermore, serum T4 levels were reduced at PND 21 in both,male and female offspring (250 and 750 mg/kg). At PND 21, Serum alkaline phosphatase (ALP) was decreased in males exposed to 750 mg/kg dietat, and females exposed to 250 and 750 mg/kg diets. At PND 46 ALP was significantly elevated in males (250 and 750 mg/kg). Variations in the cervical vertebrae and phalanges were observed in pups at PND 4 (250 and 750 mg/kg). Therefore, BFR exposure during gestation through to weaning alters developmental programming in the offspring. The persistence of BFRs in the environment remains a cause for concern with regards to developmental toxicity.
Keywords
polybrominated diphenyl ethers; brominated flame retardants; hexabromocyclododecane
Tags
IRIS
•
Hexabromocyclododecane (HBCD)
New 7/2016 (private)
Database Searches
Pubmed
Excluded/Not on Topic
OPPT REs
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_C. Engineering
Data screening total
Screening: Excluded
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Cyclic Aliphatic Bromine Cluster (HBCD)_F. Human Health
Total – title/abstract screening
Off topic
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