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3359249 
Journal Article 
Review 
Fine particulate matter air pollution and atherosclerosis: Mechanistic insights 
Bai, Y; Sun, Q 
2016 
1 
Biochimica et Biophysica Acta
ISSN: 0006-3002
EISSN: 1878-2434 
1860 
12 
2863-2868 
English 
27156486 
WOS:000384866700011 
BACKGROUND: Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous plaque in the arteries. Its etiology is very complicated and its risk factors primarily include genetic defects, smoking, hyperlipidemia, hypertension, lack of exercise, and infection. Recent studies suggest that fine particulate matter (PM2.5) air pollution may also contribute to the development of atherosclerosis.

SCOPE OF REVIEW: The present review integrates current experimental evidence with mechanistic pathways whereby PM2.5 exposure can promote the development of atherosclerosis.

MAJOR CONCLUSIONS: PM2.5-mediated enhancement of atherosclerosis is likely due to its pro-oxidant and pro-inflammatory effects, involving multiple organs, different cell types, and various molecular mediators.

GENERAL SIGNIFICANCE: Studies about the effects of PM2.5inhalation on atherosclerosis may yield a better understanding of the link between air pollution and major cardiovascular diseases, and provide useful information for policy makers to determine acceptable levels of PM2.5 air quality. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andy Ghio and Weidong Wu. 
NAAQS
• ISA-PM (2019)
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